Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial

RIGHT (ISRCTN 66434824)

The 'Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial (RIGHT)' study is a collaborative, single centre, prospective, randomised, single-blind, blinded endpoint, parallel-group, controlled trial designed to test the feasibility of:

(i) Performing stroke trials in the pre-hospital ambulance environment safety with reruitment by paramedics; and

(ii) The safety and effect of transdermal glyceryl trinitrate (a nitric oxide donor) on blood pressure in patients with hyperacute stroke

80 patients with acute ischaemic or haemorrhagic stroke will be enrolled by paramedics within 4 hours of the onset of stroke and treatment will be given for 7 days. The primary outcome is blood pressure at 2 hours post-treatment

Power point presentation, V1.0 (Powerpoint) - to be added

Status

As of 6 October 2009:

Approvals: LREC (Nottingham), MHRA, R+D: EMAS, R+D: NUH

Funding

• Division of Stroke Medicine, University of Nottingham

News

• October 2009: Second Investigator meeting to be held (Beechdale)
• September 2009: First Investigator meeting held (Queen's Medical Centre)
• April 2009: Local Research Ethics approval received

Reference numbers

• CTA ref: 03057/0033/001-0001
• EudraCT No: 2007-004766-40
• Funding: Division of Stroke Medicine, University of Nottingham
• ISRCT No: 66434824
• MREC ref: 09/H0408/5
• R&D: EMAS ref: 09/H0409/5
• R&D: NUH ref: 08SR003
• Sponsor: University of Nottingham

Documents

General

Standard Operating Procedures (SOPs) and Working Practice Documents (WPDs)

Data collection and other forms

Ethics approved documents

Supporting documents

Study personnel

Trial Steering Committee:

Trial Management Committee:

Independent Data Monitoring Committee:

Independent Events Adjudicator:

Contact details

Written by Philip Bath, last updated 6 October 2009