Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial

RIGHT (ISRCTN 66434824)

2012, March: Recruitment has now completed: 41 patients were enrolled and all have now had their final day 90 follow-up. Many thanks to all the paramedics who recruited to the trial.

The 'Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial (RIGHT)' study is a collaborative, single centre, prospective, randomised, single-blind, blinded endpoint, parallel-group, controlled trial designed to test the feasibility of:

(i) Performing stroke trials in the pre-hospital ambulance environment safely with reruitment by paramedics; and

(ii) The safety and effect of transdermal glyceryl trinitrate (a nitric oxide donor) on blood pressure in patients with hyperacute stroke

Up to 80 patients with acute presumed stroke will be enrolled by paramedics within 4 hours of the onset of stroke and treatment will be given for 7 days. The primary outcome is blood pressure at 2 hours post-treatment. Recruitment will cease in December 2011

Status

As of 31 March 2012:

Enrolled patients: 41 (Nottingham, UK)

All 41 patients have had their final follow-up at day 90, and the database is being cleaned prior o lock and analysis.

Funding

News

December 2011: Recruitment completed with 41 patients enrolled
Newsletter, September 2011 (pdf file)
Newsletter, June 2011 (pdf file)
Newsletter, May 2011 (pdf file)
Newsletter, April 2011 (pdf file)
Newsletter, March 2011 (pdf file)
October 2009: Second Investigator meeting to be held (Beechdale)
September 2009: First Investigator meeting held (Queen's Medical Centre)
April 2009: Local Research Ethics approval received

Reference numbers

CTA ref: 03057/0033/001
EudraCT No: 2007-004766-40
Funding: Division of Stroke Medicine, University of Nottingham
ISRCT No: 66434824
MREC ref: 09/H0408/5
R&D: EMAS ref: 09/H0409/5
R&D: NUH ref: 08SR003
Sponsor: University of Nottingham

Documents

Study personnel

Trial Steering Committee:

Philip Bath (Chair, University of Nottingham), Sandeep Ankolekar (University of Nottingham), Niro Siriwardena (East Midlands Ambulance Service)

Trial Management Committee:

Philip Bath (Chief Investigator, University of Nottingham), Sandeep Ankolekar (Trial Medic, University of Nottingham), Jennifer Eardley (Trial Champion, East Midlands Ambulance Service), Andrew Harrison (Trial Champion, East Midlands Ambulance Service), Niro Siriwardena (Principal Investigator, East Midlands Ambulance Service)

Independent Events Adjudicator:

Niki Sprigg (University of Nottingham)

Contact details

RIGHT Trial Office

Division of Stroke

Institute of Neuroscience

University of Nottingham

Clinical Sciences Building

City Hospital campus

Hucknall Road

Nottingham NG5 1PB

Telephone: +44 (0)115 823 1770

Fax: +44 (0)115 823 1771

E-mail: Sandeep Ankolekar

Written by Philip Bath, last updated 31 March 2012